Conclusion: Use of dinoprostone vaginal pessaries did not shorten time to delivery or improve any other birth outcome measured compared to dinoprostone intravaginal gel. Clinically significant hyperstimulation appeared more common following use of the pessary. Large randomised controlled trials are needed to confirm or refute these findings. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Conclusions: The prevalence of antithyroid Abs in an unselected pregnant population in the late first trimester was about 18%. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Conclusion: The results indicate that population health datasets can be a reliable information source; however, these datasets could be improved with more complete documentation in medical records. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Conclusions: Pregnancy and childbirth in tetraplegic women can be undertaken safely, usually with spontaneous onset of labour and vaginal delivery. However, hospitalisation for intercurrent problems is common. Management requires a multidisciplinary approach and is best undertaken in major centres with both obstetric and spinal cord injuries medical expertise. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Conclusions: Combining first and second trimester markers for Down syndrome screening better defines the at-risk population. However, integrated protocols complicate management of screening programs and may not be suitable as primary screening strategies. It may be a better use of resources to refine current first and second trimester programs through improved access and new markers. We therefore suggest thinking twice before embracing integrated population screening programs. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

We have prospectively examined the diagnostic accuracy of a conventional multiplex polymerase chain reaction (PCR) analysis of maternal plasma for fetal gender determination in daily practice. Plasma DNAs were obtained from 168 pregnant women between five and 32 weeks of gestation. The 198-bp-specific sequence on Y-chromosome and the 261 bp ATL1-gene-specific sequence on X-chromosome were coamplified in a multiplex nested PCR manner. The results of fetal sex prediction were compared with routine analysis of fetal tissues and birth outcomes. The ATL1-specific sequences were detected in all cases but Y-chromosome-specific signals were observed in 95 of 97 plasma samples of women carrying male fetuses, leading to the sensitivity of 97.9, 100 and 100% for the first, second and third trimesters...

Conclusion: Our results indicate that promoter hypermethylation is an important mechanism for loss of hMLH1 and hMSH2 expression in human ovarian cancer and may be a potential prognostic factor in ovarian cancer. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Conclusions: The long-term health of women who undergo hysterectomy is not noticeably different from a group of women who do not undergo hysterectomy. In women undergoing hysterectomy, pelvic pain, urinary frequency and depression scores are reduced five years after hysterectomy compared to prehysterectomy. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

(Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

(Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

(Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

(Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

(Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

(Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

The Institute of Medicine announces the establishment of the Norman F. Gant/American Board of Obstetrics and Gynecology (ABOG) Fellowship, which was endowed through a gift of $650,000 from ABOG. Named in honor of Norman F. Gant, M.D., a member of the Institute of Medicine and the executive director of ABOG, the fellowship will provide an exceptional learning and career development opportunity to obstetricians and gynecologists early in their careers. (Source: Institute of Medicine - All new Projects, Reports, Events and News items)

Abstract  Integration of human papillomavirus DNAs into the host genome is crucial to the development of cervical cancer. Overexpression of the P16 protein has been reported in cervical intraepithelial neoplasia (CIN) as well as cervical cancer. Such molecular biomarkers have been utilized for ancillary testing of liquid-based cytology specimens; however, their clinical application remains controversial. To detect CIN 2 or more advanced lesions, 153 liquid-based cytology (LBC) specimens were investigated to determine the physical status of the human papillomavirus (HPV) DNA by in situ hybridization (ISH) and to detect overexpression of the P16 protein by immunocytochemistry combined with HPV genotyping by polymerase chain reaction. The combination of ISH, P16 immunocytochem...

Conclusion  A line (blue line) on the top of the cavity has been observed in 33 of 47 (70.2%) cases. This line (blue line) can be used for determining the midline especially before hysteroscopic incision of uterine septum and can also shorten the operation time. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0808-zAuthors Levent Yaşar, Teyfik Saglam Caddesi, No: 11, Bakirkoy Istanbul TurkeyA. Süha Sönmez, Obstetrics and Gynecology Clinic Bakırköy Dr Sadi Konuk Research and Teaching Hospital Ayazaga Oyak Sitesi 12 Blok No 3, Şişli 80660 Istanbul TurkeyKadir Savan, Obstetrics and Gynecology Clinic Bakırköy Dr Sadi Konuk Research and Teaching Hospital Ayazaga Oyak Sitesi 12 Blok No 3, Şişli 80660 Istanbul TurkeyMurat Ekin, Obstetric...

Conclusion  Vaginal ulcer associated with long standing genital prolapse need careful evaluation (including punch biopsy) for underlying carcinoma. Treatment due to the rarity of this entity was controversial previously and current review of literature suggests surgical treatment with or without radiotherapy as the optimum treatment for early stage and radiotherapy for advanced stage vaginal carcinoma associated with genital prolapse. Early diagnosis with adequate treatment can minimize the morbidity and mortality associated with vaginal carcinoma. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-008-0815-0Authors Sharda Brata Ghosh, Maulana Azad Medical College, Lok Nayak Hospital Department of Obstetrics, Gynaecology and Pathology Delhi 110002 Ind...

We present baseline characteristics, prevalence of HPV-6/11/16/18 and, for women aged 16–23, abnormal cervical cytology and sexually transmitted diseases. Results   Chlamydia trachomatis and Neisseria gonorrhoeae prevalence was 5 and 0.3%, respectively. Approximately 17% of participants had HPV-6, 11, 16, or 18 DNA or antibodies. All subjects <17 years were naïve to the four vaccine types. Discussion  The results of the vaccine trials have demonstrated that it is worth administering prophylactic HPV vaccines before sexual debut; however, none of these sexually active German women were positive to all four types and most were positive to only one type. Thus, all women had the potential to benefit from vaccination with a quadrivalent HPV vac...

Conclusion  Hypoxic state was considered to be closely related to histological type of epithelial ovarian tumors, suggesting that CLAs may be most hypoxic. In the comparison of mucinous tumors, malignancies would not always become most hypoxic. Tumor size may not be strongly associated with hypoxic state. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0816-zAuthors Masaki Miyazawa, Tokai University Department of Pathology, School of Medicine Tokyo JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane Hidaka Saitama 350-1298 JapanMariko Fujita, Tokai University Department of Pathology, School of Medicine Tokyo JapanTakeshi Hirasawa, Tokai University Department of Obstetrics and Gy...